Application | Comment | Organism |
---|---|---|
medicine | idursulfase treatment appears to be safe and effective in adult Japanese patients with attenuated Mucopolysaccharidosis II | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
lysosome | - |
Homo sapiens | 5764 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
iduronate-2-sulfatase | - |
Homo sapiens |
idursulfase | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | male patients, ages 21-53 years, receiving weekly intravenous infusions of 0.5 mg/kg idursulfase for 12 months, show significant reductions in lysosomal storage and several clinical improvements. Idursulfase is generally well-tolerated. Infusion-related reactions occur in 50% of patients and are mostly mild with transient skin reactions that do not require medical intervention. Two infusion-related reactions are assessed as serious (urticaria and vasovagal syncope) | Homo sapiens |